Eight IRLs including LINC00461, LINC01055, ELFN1-AS1, LMO7-AS1, CYP4A22-AS1, AC079612.1, LINC01351, and MIR31HG were identified by univariate COX regression analysis, and most of them were positively correlated with poor prognosis of CRC. The gene discussed is CYP4A22; the disease is colorectal carcinoma.