Studies reported that LINC00461 played an oncogenic role in CRC cells through the NFIB signaling pathway, and mediated cisplatin resistance of rectal cancer by targeting the miR-593-5p/CCND1 axis, showing that LINC00461 may be a prognostic biomarker for CRC (Qu et al., 2020). The gene discussed is NFIB; the disease is rectal cancer.