Sasidharan et al. identified a “poor prognosis CD4 gene signature” (ppCD4sig), found that patients with high ppCD4sig score showed shorter disease specific survival and progression-free interval, which provided novel insights and a unique prognostic gene signature of CD4 + tumor-infiltrating lymphocytes in the CRC microenvironment (Sasidharan Nair et al., 2020). The gene discussed is CD4; the disease is neoplasm.