It was suggested that acquisition of a second cancer-related gene alteration may dictate the development of certain tumor types, and that TP53, IDH1, ATRX are functionally linked (Figure 5F) (20, 21). On the other hand, the most mutually exclusive pairs were PTEN-IDH1 and EGFR-IDH1 (Figure 5F). This evidence concerns the gene IDH1 and neoplasm.