High risk score group also expressed more immune checkpoint molecules including PDCD1 and chemokines CCL-5, CXCL10, and CXCL9. Functional annotation of risk score further revealed that macrophage activation, fibroblast proliferation, and regulation of T cell apoptotic process were more frequently occurred in glioma patients with high risk score. Here, CXCL9 is linked to central nervous system cancer.