TRIM59 and gastric cancer: Having analyzed the highly malignant SNU-4th cells isolated from the gastric cancer xenografts, Gong et al. provided evidence demonstrating that the EBV-encoded circLMP2A_E5_E3 likely functions as a miRNA sponge to induce and maintain cancer stemness by suppressing the anti-tumor effects of the miR-3908/TRIM59/p53 signaling, which is likely responsible for the metastasis and poor prognosis of EBV-associated gastric cancer (Gong et al., 2020).