The behavior and plasticity of muscle-resident PDGFRα+ FAPs in non-inflammatory or mild-inflammatory muscle perturbations such as mechanical denervation, neuropathies, amyotrophic lateral sclerosis (ALS), spinal cord injury, and spinal muscular atrophy (SMA) have not been explored until very recently. Here, PDGFRA is linked to amyotrophic lateral sclerosis.