HDAC2 and cardiac hypertrophy: Among the 18 mammalian HDACs, HDAC2 acts as a pro-hypertrophic regulator of cardiac hypertrophy development by modulating the GSK3β or kruppёl like factor 4 activity (Trivedi et al., 2007; Kee et al., 2008; Kee and Kook, 2009).