In addition, HDAC2 and HDAC8 expression levels are upregulated in renovascular hypertensive rats, while sodium valproate, a non-specific HDAC inhibitor, attenuates cardiac remodeling, confirming the involvement of HDAC2 and HDAC8 in cardiac remodeling (Li et al., 2017). This evidence concerns the gene HDAC8 and renovascular hypertension.