PCNA and neoplasm: The researchers verified the above conclusion by constructing an intestinal tumor model in Apcmin/+ mice, and found that compared with the control group, F. nucleatum can cause Apcmin/+ mice to exhibit high levels of proliferating cell nuclear antigen, promote cell proliferation, and increase the level of inflammatory mediators in mouse serum and myeloid cells infiltrating into the tumor, thus promoting the development of tumor (Kostic et al., 2013).