In addition, F. nucleatum also promotes the glycolysis and carcinogenesis of CRC by upregulating the histone modification of ENO1 (a key component in the glycolysis pathway) and other genes by upregulating the long non-coding RNA enolase 1 (ENO1)-intron transcript (ENO1-IT1)] (Hong et al., 2020). This evidence concerns the gene ENO1 and colorectal carcinoma.