After treatment with IL-10, the expression of col1 and col3 in KFs was significantly reduced, and the levels of TGF-β, smad2/3 and Smad4 were down-regulated, while the level of smad7 was up-regulated, suggesting that IL-10 inhibited the formation of keloid by inhibiting the classic TGF-β/Smad signal pathway of fibrosis (Shi et al., 2019). Here, TGFB1 is linked to keloid.