A similar autocrine mechanism mediated by VEGF-C and VEGFR-3 has been proposed for oral squamous (Matsuura et al., 2009; Shigetomi et al., 2018), ovarian (Decio et al., 2014; Lim et al., 2014), and mammary (Varney and Singh, 2015) carcinomas. This evidence concerns the gene FLT4 and carcinoma.