To date, the expression of VEGFR-3 has been detected in prostate cancer cells (Tsurusaki et al., 1999; Li et al., 2004; Zeng et al., 2004; Jennbacken et al., 2005; Yang et al., 2006; Yang et al., 2014), however, the pathological role of VEGFR-3 signaling remains unclear. This evidence concerns the gene FLT4 and Familial prostate cancer.