On the other hand, the expression of VEGFRs (VEGFR-1, VEGFR-2, and VEGFR-3) was up-regulated in human androgen-dependent/weakly metastatic prostate cancer LNCaP cells (4.9-, 1.9-, and 3.3-fold, respectively). This evidence concerns the gene FLT4 and Familial prostate cancer.