These DEPs including Pygl, Pklr, Pc, Ehhadh, Acox1, Fasn, Acly, Acsl1, Acsl5, Pgm1, Suclg1, Gpt, Idh1, Fh, and Adh1 maight be as target proteins of AMR and its fractions for hypothyroidism. The gene discussed is ACSL5; the disease is hypothyroidism.