ACLY and hypothyroidism: Furthermore, citric acid, a-ketoglutaric acid, and acly were significantly up-regulated in hypo-WD and a-ketoglutaric acid in hypo-CPF, hypo-LAF, and hypo-ATF groups; acly in the hypo-CPF, hypo-OSF, and hypo-ATF groups were significantly increased compared with the hypothyroidism group, suggesting that AMR and its fractions might stimulate the TCA cycle to induce the energy metabolism of hypothyroidism rats.