Compared with the hypothyroidism group, the level of T3 was significantly increased in hypo-WD, hypo-VOF, hypo-CPF, hypo-LAF, hypo-OSF, and hypo-ATF (p < 0.05); the level of T4 was significantly up-regulated in hypo-WD, hypo-VOF, hypo-CPF, hypo-LAF, and hypo-ATF (p < 0.05); the level of TSH was significantly down-regulated in hypo-WD, hypo-CPF and hypo-LAF (p < 0.05). Here, CD4 is linked to Wilson disease.