These DEPs including Pygl, Pklr, Pc, Ehhadh, Acox1, Fasn, Acly, Acsl1, Acsl5, Pgm1, Suclg1, Gpt, Idh1, Fh, and Adh1 maight be as target proteins of AMR and its fractions for hypothyroidism. Here, PKLR is linked to hypothyroidism.