These DEPs including Pygl, Pklr, Pc, Ehhadh, Acox1, Fasn, Acly, Acsl1, Acsl5, Pgm1, Suclg1, Gpt, Idh1, Fh, and Adh1 maight be as target proteins of AMR and its fractions for hypothyroidism. The gene discussed is PGM1; the disease is hypothyroidism.