In addition, possible associations between Gal-3 serum levels and SSc variants (Taniguchi et al., 2012; Stochmal et al., 2020), or between this lectin and specific clinical manifestations and laboratory markers of the disease has also been documented (Taniguchi et al., 2012; Koca et al., 2014; Yanaba et al., 2016; Faludi et al., 2017; Hromádka et al., 2017; Gruszewska et al., 2020; Stochmal et al., 2020), although with highly dissimilar results. This evidence concerns the gene LGALS3 and systemic sclerosis.