LGALS3 and systemic sclerosis: In addition, when considering all immunosuppressive treatments (IT) together and grouped patients according to this variable, we found significantly lower concentrations of Gal-1 in dcSSc patients receiving IT (171.32 ng/ml vs. 332.84 ng/ml, p = 0.02), and decreased levels of Gal-3 in total SSc patients receiving IT (1.74 ng/ml vs. 2.46 ng/ml, p = 0.044) compared to patients not receiving this treatment (Table 4).