Moreover, with regards to associations with clinical manifestations, we found significantly higher levels of Gal-1 in patients with associated telangiectasias, a phenomenon associated with endothelial dysfunction, although no association was observed with the presence of digital ulcers (DU) and pitting scars, in contrast to previous reports (Yanaba et al., 2016), calling into question the suggested protective role for Gal-1 in the development of digital vasculopathy in SSc (Yanaba et al., 2016). This evidence concerns the gene LGALS1 and telangiectasis.