Moreover, BM-MSC exosomes presents high level miR-1470 which promote the differentiation of CD4+CD25 + FOXP3+ Tregs in PBMCs of asthmatic patients by inducing the expression of P27KIP1(Zhuansun et al., 2019) In another recent study, hPMSCs were cultured with PBMCs from children with asthma, reducing CD4+ and CD8+T activation and proliferation and significantly decreasing IL-5 levels (Lin et al., 2019). Here, CD4 is linked to asthma.