MAPK8 and non-small cell lung carcinoma: The combined treatment using sesquiterpene alkaloids, dendrobine (20) and cisplatin, was also effective for inhibiting the non-small cell lung cancer cells (NSCLC) in vitro and in vivo, where the cytotoxicity was induced by the simulation of c-jun NH2-terminal kinase (JNK)/p38 stress signaling pathways, and the expression change of pro-apoptotic proteins Bax and Bim further led to the apoptosis (Figure 6, revised from song et al., 2019, created with BioRender.com).