SNCA and multiple system atrophy: A neuropathologic study on MSA showed that the glial cytoplasmic inclusions, neuronal nuclear inclusions, and diffuse homogeneous alpha-synuclein staining in neuronal nuclei and cytoplasm were distributed widely in lesions in the pontine nuclei, putamen, substantia nigra, and other parts of the brain, indicating that both presynaptic function (detected by 18F-Dopa PET) and postsynaptic pathway (detected by 18F-FDG PET) of dopaminergic neurons were impaired.