Meanwhile, the investigation of other proteins such as carbonic anhydrase, CD117/c-kit, proganulin, and kallikreins which may play roles in neural circuit development and maintenance, stress response, innate immunity, and aging as well as brain innate immunity may open a new avenue for the study of MSA (Greco et al., 2012; Dukic et al., 2016; Chitramuthu et al., 2017; Gennarini et al., 2017; Hsieh et al., 2019). This evidence concerns the gene KIT and multiple system atrophy.