To our knowledge, this is the first study to establish a clinical prediction model based on demographic and laboratory variables selected by LASSO regression analysis, including AO, DBIL, AST, eGFR, and α-synuclein, for better differentiation between MSA-C and SCA, and the model presented excellent overall availability in our specific study group. The gene discussed is SNCA; the disease is multiple system atrophy, cerebellar type.