In this context, IFN-γ-producing Th17.1 (CCR6+CXCR3+CCR4–) cells have been identified as relevant in disrupting the permeability of the BBB in MS.15 Memory B cell precursors and IFN-γ-producing CD8+ T cells also express high levels of CCR6, as they can enter the CNS. This evidence concerns the gene CD8A and myeloid sarcoma.