This novel platform is comprised of the following unique elements: (1) lentiviral particles that carry non-functional DNA (only a GFP cassette for infection validation); (2) an scFv against CD24 fused to the lentivirus envelope (VSV-G) for targeted delivery to CD24-expressing cancer cells; (3) IN-derived peptides (INS or INR) that stimulate non-functional DNA integration into the cell genome, which in turn increases the number of DSBs, thus stimulating cancer cell death. Here, CD24 is linked to cancer.