SOX2 and neoplasm: In silico analysis of GLI1 promoter (obtained from the UCSC Genome Browser assembly ID:hg38) (Supplementary Fig. 1) using the TFBIND bioinformatics software (http://tfbind.hgc.jp) revealed significant enrichment of binding motifs (wwTGnwTw) [15] for SOX2 (Fig. 1A), a well characterized transcription factor involved in stemness, drug resistance, and tumor growth [16].