In addition, the subgroup of melanoma cases with high expression of both SOX2 and GLI1 exhibited lower frequency of KRAS mutations (0.0182 vs. 0.292) and higher frequency of PTEN mutations (0.1272 vs. 0.0414) (Supplementary Fig. 4b), although the relevance of this finding needs further investigation. Here, SOX2 is linked to melanoma.