For instance, a previous study found that MLT effectively inhibits the excessive activation of PI3K-AKT pathway by cisplatin, a commonly used chemotherapeutic drug, thereby protecting and stabilizing PreOR50; MLT reduces inflammatory response in rheumatoid arthritis by inhibiting the PI3K-AKT pathway51; and MLT inhibits proliferation, invasion, and tumorigenesis of human bladder cancer cell by PI3K-AKT/mTOR/MMPs pathway52. This evidence concerns the gene AKT1 and urinary bladder carcinoma.