LEP and obesity due to melanocortin 4 receptor deficiency: Intriguingly, the culpable memory T-cell population within the WAT is transcriptionally distinct from other tissues.86 Given that leptin limits proliferation and responsiveness of regulatory T cells while having opposite effects on effector T cells,168 inflammation-skewed adipocytes secreting excess amounts of leptin might play a role in the development of the culpable hyperinflammatory memory T cells, a phenotype that might extend to viral pneumonias in obesity.