Analogous to the triple combination of HMA, venetoclax and FLT3 inhibitor as targeted agent for FLT3-mutated AML, the combination of azacitidine, venetoclax, and ivosidenib is under investigation for IDH1-mutated hematologic malignancies in an early-phase clinical trial (NCT03471260) [109]. This evidence concerns the gene IDH1 and acute myeloid leukemia.