Consistent with the increase in myocardial perivascular fibrosis, there was an increase in the expression of myocardial expression of collagen type 1 gene Col1a1. These findings support other studies in P. obesus24 that have reported increases in myocardial perivascular fibrosis and Col1a1 and has been noted in alternate rodent models of Type 1 and Type 2 diabetes5,30–32. Here, COL1A1 is linked to fibrosis.