Aβ plaques and astrocytes in 24-month old AD mice were significantly higher in comparison to age-matched WT mice (WT cortex %Aβ mean ± SEM: 0.28 ± 0.08, p < 0.001; %GFAP mean ± SEM: 6.55 ± 0.65, p < 0.001; WT hippocampus %Aβ mean ± SEM: 0.35 ± 0.12, p < 0.001; %GFAP mean ± SEM: 5.34 ± 0.31, p < 0.001). The gene discussed is GFAP; the disease is Alzheimer disease.