PSEN1 and Alzheimer disease: The double transgenic mouse model B6.Cg-Tg (APPswe, PSEN1dE9) 85Dbo/J strain (common name: APPswe/PS1dE9) expresses a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and a mutant human presenilin 1 (PS1-dE9) and, in accordance with several previous studies38–40, was used in this study as a model of AD.