In the chronic stage of infantile-onset epilepsy, DIANA-mirPath identified two gene targets of miR-451-5p (Prps2—Phosphoribosyl Pyrophosphate Synthetase 2 and Gfpt2—Glutamine-Fructose-6-Phosphate Transaminase 2) involved in multiple metabolic pathways. The gene discussed is PRPS2; the disease is infantile-onset epilepsy.