Interestingly, among subjects not on statin therapy, no difference was detected in either PCSK9 levels or EPCs number between patients with vs. those without T2DM (Fig. 2), while significantly reduced CD45neg/CD34bright (p = 0.035) and CD45neg/CD34bright/CD146neg (p = 0.032) were observed in patients with diabetes vs. patients without diabetes only among statin-treated subjects (Fig. 2B,C). This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.