Treatment of the human small-cell lung carcinoma cell line, QG90, with HA was shown to strongly activate secretion of MMP2 while expression of antisense CD44s in QG90 cells or pretreatment of cells with the neutralizing anti-CD44 antibody, blocked the HA-dependent secretion of MMP2, highlighting the role of HA-CD44 signaling in HA-dependent MMP2 secretion90. Here, CD44 is linked to small cell lung carcinoma.