Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that along with its family members composed of HA receptors (CD44, cluster of differentiation antigen 44; RHAMM, hyaluronan-mediated motility receptor), HA synthases (HAS1, HAS2, HAS3), and hyaluronidases, promotes tumor growth and progression17–27. The gene discussed is CD44; the disease is neoplasm.