A decrease in platelet count is to be expected and has been observed in immunocompetent mice infected with DENV-258; however, the slight thrombocytosis at 72 hpi, which was also observed in mice infected with DENV-364 (unpublished data), could be a response to factors triggered by infection that increase thrombopoietin production76. Here, THPO is linked to thrombocytosis disease.