TMPRSS2 and obesity due to melanocortin 4 receptor deficiency: Results showed that a model including age, systemic arterial hypertension, diabetes, obesity and TMPRSS2/ACE2 minimized the Akaike Information Criteria (AIC = 97.11), suggesting that TMPRSS2/ACE2 ratio outperforms ACE2 expression predictive power to model COVID-19 respiratory outcome in this cohort (Supplementary Table 3).