Moreover, SIRT1 knockdown reversed the effect of TM4SF1 overexpression on the percentages of SA-β-gal- and SAHF-positive cells (Fig. 7B–E), as well as the protein level of p21 in B7-H3 knockdown CRC cells treated with low-dose DOX (Fig. 7A). This evidence concerns the gene CD276 and colorectal carcinoma.