ZSWIM6 and Acromelic frontonasal dysplasia: In 2014, a de novo variant in the zinc finger SWIM-type containing 6 gene (ZSWIM6) was commonly identified in four patients with acromelic frontonasal dysostosis (MIM #603671)1, a rare disorder characterized by distinct craniofacial, brain, and limb malformations, including frontonasal dysplasia, interhemispheric lipoma, agenesis of the corpus callosum, tibial hemimelia, preaxial polydactyly of the feet, and intellectual disability2.