Moreover, E-cadherin protein expression was upregulated in AGS and NCI-N87 cells transfected with si-circ_0000144 when compared with si-NC group, but these effects were alleviated by miR-217 inhibitor, showing that the EMT was suppressed by circ_0000144 silencing and partly reversed by downregulated miR-217 in GC cells (Figs. 6E and 6F). The gene discussed is CDH1; the disease is gastric cancer.