Our findings showed, for the first time, the strong potential of methanolic extract from the body wall sea cucumber extract (BWMT) in inhibiting the progression of the advanced-stage prostate cancer cell line PC3 by inducing apoptosis and inhibiting metastasis via the enhancement of intracellular ROS level through activation of JNK/p38 and downregulation of ERK pathways, respectively. This evidence concerns the gene MAPK8 and prostate cancer.