In contrast to nonselective NSAIDs like ibuprofen, COX-2–selective inhibitors (e.g., Celecoxib) preferentially block COX-2 activity over COX-1 activity and are prescribed to adults for the management of osteoarthritis, rheumatoid arthritis, and acute pain (Schattenkirchner, 1997; Zarghi & Arfaei, 2011; Zweers et al, 2011). Here, PTGS2 is linked to rheumatoid arthritis.