Extensive data suggest that dysregulated MARCKS expression drives the development and progression of several solid tumors including melanoma [11, 102, 103], glioma [12, 104, 105], renal cell carcinoma [106], lung cancer [107–109], colorectal cancer [110, 111], liver cancer [13, 112], and breast cancer [113–115]. The gene discussed is MARCKS; the disease is hereditary clear cell renal cell carcinoma.