Furthermore, by inhibiting the phosphorylation or overall expression of MARCKS, an increase in the sensitivity of MM cell lines to different classes of anti-myeloma drugs including proteasomal inhibitor bortezomib, corticosteroid dexamethasone, anthracycline antibiotic doxorubicin and immunomodulatory drug lenalidomide was observed. This evidence concerns the gene MARCKS and plasma cell myeloma.