Besides, the inducible neutrophil-specific NUMA-RARA expression mouse model, hCG-NUMA-RARA transgenic mouse, was also constructed, and it definitely reproduced the human APL-like phenotype in mouse, in which its RXRA interaction was required for the transformative activity of NUMA-RARA [59]. The gene discussed is RARA; the disease is acute promyelocytic leukemia.