RARA and acute promyelocytic leukemia: Interestingly, the same FIP1L1-RARA transcript, whose breakpoint was at exon-15 of FIP1L1 and the exon-3 of RARA, generated not only APL but also juvenile myelomonocytic leukemia [80], indicating the plasticity of FIP1L1-RARA-positive leukemic initial cells.