In Jie Zhao et al.’ report, MLL-ELL combined with RPRD2-MLL and MLL-AF1Q were identified in two PML-RARA-negative patients respectively, while MLL-SEPT6 was found in one PML-RARA-positive patient, indicating MLL rearrangement could resemble APL [20]. The gene discussed is KMT2A; the disease is acute promyelocytic leukemia.