Few LCA-associated genes like CEP290, ALMS1, IFT140, and IQCB1 also contribute to other syndromes such as Joubert syndrome, peroxisomal disease, Alstrom syndrome, Batten disease, and Senior Loken syndrome with similar ocular manifestations as observed in LCA. The gene discussed is IQCB1; the disease is Leber congenital amaurosis.