We found that the serum markers of cardiomyocyte injury (HBDH, CK and cTnI) increased significantly after CLP (Fig. 1d, HBDH: CLP 12 h group 1210 ± 246.2 versus sham group 158.2 ± 14.41, p < 0.0001; CK: CLP 12 h group 14,238 ± 2293 versus sham group 2229 ± 582.7, p < 0.0001; cTnI: CLP 12 h group 115.1 ± 30.8 versus sham group 36.35 ± 7.167, p < 0.0001), which indicated that sepsis induced cardiomyocyte injury in the first 12 h. The gene discussed is TNNI3; the disease is Sepsis.