In a cell model of Parkinson’s disease related to mutations in PTEN-induced putative kinase 1 (PINK1), the failure of mitochondrial Ca2+ efflux in neurons deficient in PINK1 was linked to the impaired activity of NCLX, which resulted in mitochondrial Ca2+ overload and suggested that PINK1 regulated the activity of NCLX [13, 14]. Here, PINK1 is linked to Parkinson disease.