This “COVID-19-associated coagulopathy” in early infection reflects abnormalities in coagulation tests (initially high D-dimer and fibrin/fibrinogen-degradation products and later high activated partial thromboplastin time (aPTT) and prothrombin (PT) [3, 15, 48]), but does not fulfill the usual definition of a clinical coagulopathy in which there is bleeding. Here, F2 is linked to blood coagulation disease.