One concern with all of the studies we collectively do in our mouse models of AD pathology is that they are kept in relatively sterile conditions (e.g., specific pathogen free housing), meaning that they are subject to limited immune priming [58, 59]. Herein, we explored how immune priming via constitutive expression of Il6 or Il10 influenced subsequent passive Aβ immunotherapy. Here, IL6 is linked to Alzheimer disease.