Even though circ_NRIP1 was clarified as one of top upregulated circRNA in ESCC, colorectal cancer and breast cancer, Li et al. [24] observed top ten reduced circRNAs including circ_NRIP1 in gastric cancer patients’ plasma, and this probably was the rare research announcing upregulation of circ_NRIP1 in cancer-related patients. This evidence concerns the gene NRIP1 and esophageal squamous cell carcinoma.