Even though circ_NRIP1 was clarified as one of top upregulated circRNA in ESCC, colorectal cancer and breast cancer, Li et al. [24] observed top ten reduced circRNAs including circ_NRIP1 in gastric cancer patients’ plasma, and this probably was the rare research announcing upregulation of circ_NRIP1 in cancer-related patients. The gene discussed is NRIP1; the disease is cancer.