Treatment with inhibitor zafirlukast, a compound stabilizing non-functional conformational state of TNFR1 [29], returned the ALDH activity level in engineered melanoma cells A375hTNFa to the level of ALDH activity in parental cells (83.5% vs. 85.4% of ALDH+ cells, unpublished data). Here, TNFRSF1A is linked to melanoma.