Molecular analysis of the iBMCs from the 5 and 7 months cohort suggested progressive gene expression dysregulation consistent with leukemogenesis (Fig. 3), including increased cell survival/proliferation (Akt, NF-κB and Wnt) and decreased apoptosis/tumor suppression (JNK, C/EBPδ and PTEN). Here, AKT1 is linked to neoplasm.