IgG/M isotypes of anti-β2GPI, anti-CL, and/or lupus anticoagulant (LA) positivity, comprise the laboratory criteria for classification of the antiphospholipid syndrome (APS).1 Additionally, aPL of the immunoglobulin (Ig) A isotype is now included in the two most recent sets of classification criteria for systemic lupus erythematosus (SLE).2,3. The gene discussed is APOH; the disease is systemic lupus erythematosus.