SUB1 and cancer: Although there are few biological functions about PC4 in vivo(Swaminathan et al., 2016), our and others’ studies have demonstrated that PC4 is participated in transcriptional activation, oxidative stress, and genomic stability, cancer development and reprogramming of somatic cell in vitro, suggesting that PC4 is an important and multifunctional protein (Garavis & Calvo, 2017; Jo et al., 2016; Mortusewicz et al., 2016; Yu et al., 2016).