CALCA and infection: An approximate two-fold lower bacterial burden was detected in the CGRP-neutralized cohort when compared to the vehicle cohort (Fig 7F, Student’s t-test, p = 0.02) along with a reduction in the corneal pathology score (Fig 7F, Mann-Whitney U test, p = 0.0032), indicating that inhibition of CGRP-induced signaling improves the host clearance and corneal pathology outcomes following infection with this pathogen by likely altering neutrophil functionality.