IL4 and neoplasm: Significant decreases in the expression of cytokines are associated with tumor-associated macrophages (TAMs), including IL-4, IL-10 CCL-2, CCL-22, and CXCl-12 (see Table I in the Supplementary Material), and suggest that the reduction in macrophages within the treated tumors could be indicative of a decrease in TAMs [57], [58].