CFTR and cystic fibrosis: 1999; He et al. 2019). GL-67 was complexed to the CFTR gene and delivered to the lungs via nebulization and intranasal administration, resulting in ∼25% restoration of the chloride channel function in the lungs of CF patients (Alton et al. 1999). However, the lipid-DNA complex induced a minor pro-inflammatory response, possibly due to internalization of the complex by AM (Alton et al. 1999; Merkel and Kissel 2012).