The frequency of KRAS mutations varies among distinct populations, accounting for approximately 25% in Whites and < 10% in East Asians.11KRAS driver mutations are mostly located in codons 12 and 13, and the most frequent one is the p.Gly12Cys (c.34G>T) mutation.12-18 In lung cancer, KRAS mutations are associated with smokers and with a more aggressive phenotype.12,19-22 Efforts have been made in the past decade for rendering KRAS mutations susceptible to targeting.23 However, until lately, KRAS-mutated tumors were, unfortunately, undruggable.10 This evidence concerns the gene KRAS and lung cancer.