CALR and colorectal adenocarcinoma: We also extensively tested another human cell line—colorectal adenocarcinoma LoVo—and confirmed that BoxA‐induced CD47 surface downregulation is associated with the exposure of calreticulin on the plasma membrane, the release HMGB1 in the medium, and the activation of the three arms of the UPR (Fig EV4, EV5, EV6).