To test whether targeting HMGB1 is beneficial or detrimental in immunocompetent tumor‐bearing hosts, we set up a syngeneic model of MM, where mouse AB1 malignant mesothelioma cells are grafted into the peritoneum of syngeneic BALB/c mice (Mezzapelle et al,2016). Here, HMGB1 is linked to neoplasm.