CALR and colon adenocarcinoma: First, we investigated the effect of BoxA on the mouse colon adenocarcinoma cell line CT26: It induced calreticulin exposure (Figs 5A and EV5A), HMGB1 release (Fig 5B), the activation of the three arms of the UPR (Figs 5C and EV5B and C), and the depletion of surface CD47 (Fig 5D), without inducing cell death but merely inhibiting cell growth (Figs 5E and F, and EV5D).