In contrast, Tregs, which are known as major immunosuppressive cells in the tumor microenvironment, seem to limit TA-HEV development in tumors as revealed by the induction of MECA-79+ TA-HEVs following depletion of Foxp3-expressing cells in Foxp3DTR mice [282, 291]. The gene discussed is FOXP3; the disease is neoplasm.