KCND3 and heart disorder: In addition, other routes of CaMKII activation (i.e., nitric oxygen species, dO-GlcNAcylation; Erickson, 2014) or negative regulators of CaMKII activity (i.e., Kv4.3 subunit; Keskanokwong et al., 2011) may be different across the LV wall during cardiac disease.