Increased RYR phosphorylation at serine 2814 by CaMKII has been implicated in arrhythmogenesis in cardiac disease (Ai et al., 2005; Belevych et al., 2017; Dries et al., 2018; Fischer et al., 2014; Maier et al., 2003; Sag et al., 2009). Here, CAMK2G is linked to heart disorder.